One of the major objectives aiming at the socio-economic development of the European Union is based on the concept of knowledge-based development. In this regard, the European Commission lays a special stress on the knowledge management components, in matters of community financing. Special attention is paid to actions involving scientific research, rational data structuring, scientific innovation, participatory innovation, and knowledge transfer, and also to the knowledge communities built up by the actors and agents of the socio-economic systems that are trademark of the European communities. Accordingly, the
main challenges of the projects funded by the European Commission are as follows: getting access to practical knowledge within the socio-economic systems, identifying issues in a system starting from the experience of the stakeholders, and turning these stakeholders into actors and agents of knowledge within a system. In this communication, we would like to introduce a model of good practices in terms of collaboration and co-interest of the stakeholders in the agrifood systems from the North-East Development Region of Romania. The methodology engaged here is based on a systemic approach, namely a model of quadruple helix collaboration and knowledge management focused on a mutual endeavor of identifying specific issues and possible solutions.